Stem Cells & Growth Factor

New Tissue Regeneration Technologies

Platelet alpha granules contain potent growth factors necessary to begin tissue repair and regeneration at the wound site. Concentrated autologous platelets contain large reservoirs of growth factors that have the potential to greatly accelerate the normal healing process, naturally. The use of concentrated growth factors is considered by many to be a “new frontier" of clinical therapy and creates a paradigm shift affecting all segments of the medical profession.

NEW STANDARDS OF CARE

Leading clinicians in specialties such as dental, ENT, and facial plastic and reconstructive surgery routinely use concentrated platelets due to their ability to deliver a cocktail of bioactive growth factors. Growth factors shown to enhance the body’s natural healing process include:

• Platelet Derived Growth Factors (PDGF) initiate connective tissue healing including bone regeneration and repair.1 PDGF also increases mitogenesis (healing cells), angiogenesis (endothelial mitosis into functioning capillaries), and macrophage activation (debridement of the wound site and second phase source of growth factors).2
• Transforming Growth Factor Beta (TGF-ß) increases the chemotaxis and mitogenesis of osteoblast precursors and they also stimulate osteoblast deposition of the collagen matrix of wound healing and bone regeneration.3
• Epidermal Growth Factors (EGF) induce epithelial development and promote angiogenesis.4
• Vascular Endothelial Growth Factors (VEGF) have potent angiogenic, mitogenic, and vascular permeability enhancing activities specific for endothelial cells.4

IMPROVING PATIENT OUTCOMES

Clinicians have reported that the use of growth factors from platelet rich plasma (PRP) can enhance:

• Bone Growth and Maturation
• Graft Stabilization
• Wound Sealing
• Wound Healing
• Hemostasis

1. Marx, R.E. , et al,“Platelet-Rich Plasma Growth Factor Enhancement for Bone Grafts”, Oral Surg Oral Med Oral Patrhol, 1998;85:638-646.
2. Antonaides, H.N., et al,“Human Platelet-Derived Growth Factor: Structure and Functions”, Federation Proceedings, 1983;42:2630-2634.
3. Pierce, G.F., et al,“PDGF-BB,TGF-ß1 and Basic FGF in Dermal Wound Healing: Neovessel and Matrix Formation and Cessation Repair”, Am J Pathology, 1992;140:1375-1388.
4. “ELISA Immuno Assay For PDGF-A, Human VEGF, TGF-ß1, and Human EGF”, R&D Systems, Mpls, MN 199.

To learn more about how Dr. EDward M. Amet uses stem cells in Overland Park, Kansas, please call Reconstructive and Implant Dental Center at 913-534-8801 and schedule a consultation with our prosthodontist. We look forward to hearing from you!